Webinar: Update on Tryptase Research
Watch the recording of this webinar.
TITLE: “Trypped Up by Tryptase?” An Update on Tryptase Research at NIH
PRESENTER: Joshua Milner, M.D. Chief of the Allergy Lab (NIAID), Genetics and Pathogenesis at NIH (National Institute of Health).
Sponsored by www.BodySupportStore.com
About our speaker: Dr. Joshua Milner
- Joshua Milner. MD graduated with an S.B. in biology from the Massachusetts Institute of Technology (MIT) in 1995
- He completed his M.D. with distinction in immunology from the Albert Einstein College of Medicine.
- Dr. Milner completed his residency in pediatrics at the Children’s National Medical Center in Washington, DC.
- He was a recipient of the Pediatric Scientist Development Program Fellowship and did his fellowship in allergy and immunology at NIAID.
- Dr. Milner completed a postdoctoral fellowship with Dr. William E. Paul, NIAID, examining issues of mouse T-cell receptor repertoires before beginning as a clinical tenure-track investigator in the LAD.
- He was named chief of the LAD in 2017.
- Dr. Milner is an elected member of the American Society for Clinical Investigation and the Association of American Physicians
- He is the recipient of the Phadia Allergy Research Forum Award, as well as the Drukier Prize in Pediatric Research from Cornell University.
Ma CA, Stinson JR, Zhang Y, Abbott JK, Weinreich MA, Hauk PJ, Reynolds PR, Lyons JJ, Nelson CG, Ruffo E, Dorjbal B, Glauzy S, Yamakawa N, Arjunaraja S, Voss K, Stoddard J, Niemela J, Zhang Y, Rosenzweig SD, McElwee JJ, DiMaggio T, Matthews HF, Jones N, Stone KD, Palma A, Oleastro M, Prieto E, Bernasconi AR, Dubra G, Danielian S, Zaiat J, Marti MA, Kim B, Cooper MA, Romberg ND, Meffre E, Gelfand EW, Snow AL, Milner JD. Germline hypomorphic CARD11 mutations in severe atopic disease. Nat Genet. 2017 Jun 19. doi: 10.1038/ng.3898. [Epub ahead of print].
Ma CA, Xi L, Cauff B, DeZure A, Freeman AF, Hambleton S, Kleiner G, Leahy TR, O’Sullivan M, Makiya M, O’Regan G, Pittaluga S, Niemela J, Stoddard J, Rosenzweig SD, Raffeld M, Klion AD, Milner JD. Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticarial, dermatitis, and diarrhea. Blood. 2017 Feb 2;129(5):650-653.
Lyons JJ, Liu Y, Ma CA, Yu X, O’Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegal AM, Stone KD, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD. ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans. J Exp Med. 2017 Jan 26. pii: jem.20161435.
Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Lui Y, O’Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nat Genet. 2016 Dec;48(12):1564-1569.
Hox V, O’Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD. Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol. 2016 Jul;138(1):187-99.
Zhang Y, Yu X, Ichikawa M, Lyons JJ, Datta S, Lamborn IT, Jing H, Kim ES, Biancalana M, Wolfe LA, Dimaggio T, Matthews HF, Kranick SM, Stone KD, Holland SM, Reich DS, Hughes JD, Mehmet H, McElwee J, Freeman AF, Freeze HH, Su HC, Milner JD. Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment. J Allergy Clin Immunol. 2014 May;133(5):1400-1409.
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